Description
Molgramostim, also referred to as granulocyte-macrophage colony-stimulating factor (GM-CSF), is a protein secreted by macrophages, and stimulates stem cells to produce granulocytes and macrophages. In addition, it stimulates the functional activity of mature cells, inhibits the migration of neutrophils, is chemotactic for neutrophils and monocytes, and enhaces the ability of neutrophils to kill antibody-coated tumor cells and phagocytose bacteria and parasites.
Molgramostim is a 127 amino acid protein produced by recombinant DNA technology, expressed in Escherichia coli (E.coli) bacteria. Recombinant GM-CSF has a molecular weight of approximately 14.000 Daltons (14 kDa). The protein has an amino acid sequence that is, with one exception, identical to the natural sequence predicted from human DNA sequence analysis. Because Molgramostim is produced in E.coli, the product is non-glycosylated and thus differs from GM-CSF isolated from a human cell.

Indications
· Neutropenia
· Leukopenia